Cognitive · vrlandmarkgame

Landmark

Visual-Spatial Memory, Working Memory, Visual Attention

Live Included in CognitionVR
A virtual reality-based cognitive task, founded on the concept of Paired Associates Learning (PAL). In this task, the subject must memorize the association between shapes and their spatial locations on a virtual table. It is a targeted therapy for viewpoint-independent spatial memory.
Landmark

Introduction video

Gameplay

Initially, several specific locations on a virtual table are presented to the subject, where various shapes are displayed in these positions to allow the subject to memorize the association between each shape and its spatial location. Once the stimuli are removed, depending on the task phase, the subject is asked questions such as: “Where was this shape?”, “What was here?”, “What has changed?”, or “What was between these two shapes?”, requiring the subject to retrieve the stored information. As the levels progress, the delay between encoding and recall increases, the number of objects and locations grows, and factors such as sequential presentation, table rotation, visual distractors, and time limits are introduced. These elements progressively increase the demand on visual-spatial memory, working memory, and visual attention.

Therapeutic purpose

The therapeutic objective of this exercise is to strengthen visual-spatial memory, enhance object-location learning, and improve the ability to retrieve spatial information. (Functionally dependent on the hippocampus. A distinguishing feature of this task is the dissociation between allocentric memory—independent of the individual’s viewpoint—and egocentric memory—dependent on the individual’s current position. This distinction in spatial memory assessment is specifically linked to hippocampal function.) The subject must be able to memorize object positions within the environment, maintain spatial relationships between them, and accurately retrieve stored information even after changes in conditions or viewpoint. By engaging working memory, visual attention, and change detection, this exercise can be integrated into cognitive rehabilitation programs to preserve or enhance memory functions.

Target Population:

  1. Individuals with Mild Cognitive Impairment (MCI).
  2. Individuals in the early stages of Alzheimer’s disease.
  3. Elderly individuals with age-related complaints or deficits in memory and visual-spatial memory.
  4. Individuals experiencing memory or cognitive deficits following a stroke.
  5. Individuals with impairments in visual-spatial memory and object-location association learning.
  6. Note: This task is specifically designed to differentiate hippocampal-dependent memory deficits from other types of amnesia.

Clinical Applications:

  1. The Landmark task is suitable for use in settings such as hospitals, cognitive rehabilitation centers, neurology clinics, occupational therapy centers, geriatric rehabilitation facilities, and post-stroke recovery centers.

Clinician guide

Place the VR headset correctly on the subject’s head and prepare the training environment.

Start the exercise from a simpler level; the difficulty will increase progressively based on the subject’s performance.

Recorded metrics

  1. Fine error separation: knew the object but not its place? fooled by a look-alike?
  2. The drop caused by island rotation (viewpoint-independent memory)
  3. How long a delay between viewing and recall is tolerated

Science & evidence

Landmark targets spatial memory and object–place binding — the domain most sensitive to early memory change — together with viewpoint-independent (allocentric) representation.

Scientific basis

The hippocampus builds a "cognitive map" of space (O'Keefe & Nadel, 1978). Short-term topographical memory depends on an intact hippocampus; the Four Mountains Test (Hartley et al., 2007) measures exactly this by shifting the viewpoint. By rotating the island between viewing and answering, Landmark forces the patient to remember object locations independently of their own position.

Use in the cognitive treatment pathway

Mild cognitive impairment and early-stage Alzheimer's, age-related spatial forgetfulness and post-stroke memory deficits are targets. Separating errors (knew the object but not its place? fooled by a look-alike?) and the drop caused by island rotation build a precise profile of the memory deficit.

VR & digital evidence

A VR navigation test differentiated mild cognitive impairment on an entorhinal-cortex basis (Howett et al., 2019), and the Four Mountains Test shows high sensitivity for pre-clinical Alzheimer's (Chan et al., 2016).

This exercise is a rehabilitation aid, not a substitute for clinical assessment or therapy; program selection and interpretation of results remain with the care team.

References

  1. O'Keefe J, Nadel L. The Hippocampus as a Cognitive Map. Oxford University Press; 1978.
  2. Hartley T, Bird CM, Chan D, et al. The hippocampus is required for short-term topographical memory in humans. Hippocampus. 2007;17(1):34–48. doi:10.1002/hipo.20240
  3. Howett D, et al. Differentiation of mild cognitive impairment using an entorhinal cortex-based test of virtual reality navigation. Brain. 2019;142(6):1751–1766. doi:10.1093/brain/awz116
  4. Chan D, et al. The 4 Mountains Test: a short test of spatial memory with high sensitivity for the diagnosis of pre-dementia Alzheimer's disease. Journal of Visualized Experiments. 2016;(116):e54454. doi:10.3791/54454

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